Letrozole, gonadotropin, or clomiphene for unexplained infertility. N Engl J Med. Number of motile spermatozoa inseminated and pregnancy outcomes in intrauterine insemination. Fertil Res Pract. Poor success of gonadotropin-induced controlled ovarian hyperstimulation and intrauterine insemination for older women. Fertil Steril. Predictive factors for pregnancy after intrauterine insemination IUI : An analysis of cycles and a review of the literature.
Pregnancy predictors after intrauterine insemination: analysis of cycles in couples. J Reprod Infertil. Allahbadia, GN. Intrauterine insemination: Fundamentals revisited. J Obstet Gynecol India. Planned Parenthood. What is intrauterine insemination? Fertility and Sterility. Your Privacy Rights. To change or withdraw your consent choices for VerywellFamily. At any time, you can update your settings through the "EU Privacy" link at the bottom of any page.
These choices will be signaled globally to our partners and will not affect browsing data. We and our partners process data to: Actively scan device characteristics for identification. I Accept Show Purposes. Table of Contents View All. Table of Contents. Fertility Medications. Fertility Factors. Number of Cycles to Try?
An Overview of Fertility Treatments. What Is IUI? Getting Pregnant With Unexplained Infertility. Age Pregnancy Rate Delivery Rate 20 to 30 Was this page helpful? Human Reproduction A pregnancy rate of 5. Fertility and Sterility, IVF — when to move on? The short answer is to move on to IVF after 3 failed IUIs If the fertility problem is due to a lack of ovulation, maybe try a few more If the female is under 30 and ovarian reserve is good, maybe try a few more Costs of fertility treatments are a big factor in deciding when to move beyond IUI If the female is 40 or older, or ovarian reserve low, consider moving to IVF sooner In vitro fertilization is the next step after IUIs — with a much higher success rate The have been and continue to be many advances with in vitro fertilizationtechnology that resulted in higher odds for success.
However in the case of IUI there have not been significant advances in the last 30 years. Methods to properly process the semen were figured out long ago. The rest of the equation with IUI is interaction between sperm and the female genital tract — and between sperm and egg if female anatomy and sperm quality allow them to get together.
Since so much is left to nature with IUI, there is not much that we can improve on The sperm must swim to the end of the fallopian tube where the egg should be The egg has to be able to ovulate from the ovarian follicle and be picked up by the tube The sperm must find and fertilize the egg These steps are forced with IVF but are left to nature with IUI.
IUI What is the difference in pregnancy rates for couples with fertility problems between trying with regular intercourse versus IUIs? Several studies have addressed this question Some studies show no improvement in success with 2 inseminations done on sequential days compared to 1 well-timed IUI Others show higher success if 2 inseminations are done on back to back days One explanation for the different findings is that if single inseminations are not ideally timed for ovulation, success rates could improve with a double insemination protocol.
Then,at least one of the insems might be properly timed. Most fertility specialists believe that 1 well-timed IUI is sufficient IUI success using donor sperm is discussed on the donor insemination page. We are here to answer any questions or concerns you may have so that you feel completely confident when taking the first step toward building your family.
Patient Resource Center. Patient Portal. Request a Consult. What are success rates with inseminations? Chanced for success with intrauterine insemination will be very different in different subgroups of couples depending on the age of the female and the underlying cause of the infertility problem. This is due to the significant impact of female age on fertility Drug assisted IUI success rates Insemination treatment combined with ovarian stimulation with Clomid tablets clomiphene citrate vs.
Many studies have shown that IUI plus ovarian stimulation gives a higher success rate than insemination in natural menstrual cycles no stimulation.
When we stimulate the ovaries with drugs and do insemination we are basically blasting away with sperm and eggs and maximizing timing. The goal of ovarian stimulation with medications is to produce additional follicles so that there are more eggs available for fertilization, thereby increasing the chances of conception that month. Singletons involve much lower risk to both mother and fetus and are the goal for most doctors and fertility practices. Most women pairing a medicated cycle with IUI will not be allowed to proceed with IUI if they are growing 4 or more follicles.
Studies have shown that multi-follicular growth is associated with increased pregnancy rates in IUI with controlled ovarian hyperstimulation COH. Be warned however that more follicles also equals a higher rate of twins, triplets, etc. Most, but not all, IUI cycles are paired with fertility medications to stimulate the follicles to produce additional eggs. What your fertility specialist recommends will be based on your medical history, diagnosis, and preferences.
Using medications, the specific type, and the dosage used all affect IUI success rates. Clomid and Letrozole are both oral medications that message the brain to send stronger signals to the ovaries to ovulate, while Gonadotropin is an injectable medication that stimulates the ovaries directly to produce more follicles. The goal is always to maximize the number of eggs hence boosting chances for conception while limiting the risk of multiple pregnancies.
It is however important to note that although Clomid and Letrozole have similar odds of producing a live birth, letrozole generally has fewer side effects and more importantly, produces more singleton births. Both fresh and frozen sperm can be used successfully with IUI. When fresh is an option, it is preferred. In part, because there is an expected loss of sperm in the thawing process, but also because timing is even more critical with washed thawed sperm. Washed fresh sperm survive about hours, while washed thawed sperm only have a lifespan of hours.
Fresh sperm tend to live a bit longer which can improve the chances of conception. One study compared pregnancy rates using fresh sperm versus cryopreserved sperm for IUI. After one cycle, pregnancy rates were higher for fresh sperm vs. Many fertility specialists would agree that the timing of the IUI and an adequate concentration of sperm, or total motile count TMC , are really the more important factors. In recent years, nurse practitioners and registered nurses have started to perform greater numbers of IUI procedures.
One study compared IUI success rates performed by a registered nurse, an attending physician, and a fellowship-trained physician and found no significant difference in pregnancy or live birth rates depending on who performed the insemination. While there are lots of factors that influence IUI success rates, provider type does not appear to be a significant one. With natural conception, we tend to look at success over 6 months to a year of trying repeatedly month after month. This is somewhat true of IUI as well, but only up to a certain point.
Knowing when to move on to more advanced treatment like IVF is important for your emotional and financial well-being. If after IUIs you have not been successful, success rates flatten out and it is statistically unlikely to work for you. At this point, the cost of IUI per live birth begins to skyrocket making IVF the more cost-effective treatment on a per live birth basis.
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